The Digital Negative Alchemy (DNA) Collection has slowly developed during my twenty years of living with multiple sclerosis. It was born out of a career void after losing the ability to fully engage in my traditional wilderness photography fieldwork. To help fulfill my creative appetite this eclectic endeavor was originally pursued only for that purpose. The Collection is derived from original photographs that have evolved into distinctly new composition forms through the interaction and synthesis of imagination with core pixel content. To preserve DNA integrity no visual content is imported or cloned from other compositions. Commonly, the first phase of this visual evolution is equivalent to simple cell division, but from there forward no formulas dictate an image’s path of evolution. Compositions are rendered unique and take on their own lives when exposed to the environment of creative spontaneity. Most images are enigmatic illusions and often whimsical. Observers experience each visual representation at its current position on an evolutionary timeline. By autumn 2018 the collection had grown substantially, including numerous iterations of original individual compositions. Natural selection is underway, two-thirds will go extinct. On the web, distance and angle, screen size and viewing duration affect perception revealing hidden figures within. Larger fine art prints will likely offer observers more immersive experiences than viewing on device monitors.